The debut airs tonight at 11 p.m. ET/PT following a new episode of "The Ultimate Fighter: Live."
Parts two and three air in the same timeslot over the next two weeks. FUEL TV airs replays of each episode air throughout the week.
"UFC 146: Dos Santos vs. Mir" takes place May 26 at Las Vegas' MGM Grand Garden Arena. The night's main card, which features a full slate of heavyweight matchups, airs on pay-per-view following prelims on FX and Facebook.
Dos Santos, of course, was slated to face former Strikeforce champion Alistair Overeem in the UFC 146 main event. However, a pre-fight drug test flagged Overeem for elevated levels of testosterone, and UFC officials pulled the later-suspended fighter from the card in favor of Mir.
Mir enters the fight on the strength of a three-fight win streak. The former heavyweight champion is 8-2 in his past 10 fights and has downed Antonio Rodrigo Nogueira, Roy Nelson and Mirko "Cro Cop" Filipovic in his past three outings.
The full UFC 146 card includes:
MAIN CARD (pay-per-view)
Champ Junior Dos Santos vs. Frank Mir (for heavyweight title)
Antonio Silva vs. Cain Velasquez
Dave Herman vs. Roy Nelson
Shane Del Rosario vs. Stipe Miocic
Mark Hunt vs. Stefan Struve
Diego Brandao vs. Darren Elkins
Edson Barboza vs. Jamie Varner
C.B. Dollaway vs. Jason "Mayhem" Miller
Paul Sass vs. Jacob Volkmann
Dan Hardy vs. Duane "Bang" Ludwig
Kyle Kingsbury vs. Glover Teixeira
Mike Brown vs. Daniel Pineda